2010;126(6):1504-1512. Zhang ZW, Patchett SE, Perrett D, Katelaris PH, Domizio P, Farthing MJ. 1998;36(3):143-147. (PubMed), 117. A 2013 systematic review identified 11 randomized controlled studies that evaluated the effect of vitamin C on asthma (eight trials) or exercise-induced bronchoconstriction (three trials) (180). 2008;7:35. SVCT-2 in breast cancer acts as an indicator for L-ascorbate treatment. J Urol. Am J Clin Nutr. Lykkesfeldt J, Christen S, Wallock LM, Chang HH, Jacob RA, Ames BN. Angioplasty involves temporarily inserting and inflating a tiny balloon into the clogged artery to help restore the blood flow to the heart. Am J Obstet Gynecol. In a 1974 radio interview, he noted that "the first 250 mg is more important than any later 250 mg. 1999;281(24):2289-2293. Int J Vitam Nutr Res. Roswall N, Olsen A, Christensen J, et al. (PubMed), 11. Int J Cancer. Chen GC, Lu DB, Pang Z, Liu QF. Stephen R, Utecht T. Scurvy identified in the emergency department: a case report. In contrast, trials are intervention studies that can establish a causal relationship between an exposure and an outcome, e.g., by evaluating the effect of vitamin C supplementation on the incidence of chronic disease in participants randomly assigned to receive either vitamin C or placebo for a given length of time. Does vitamin C deficiency affect cognitive development and function? Cochrane Database Syst Rev. One trial found that vitamin C supplementation (1 g/day) for 14 weeks reduced the risk of asthma attacks precipitated by respiratory infection. Supplemental Forms | Linus Pauling Institute | Oregon State University Stamp LK, O'Donnell JL, Frampton C, Drake JM, Zhang M, Chapman PT. 1997;15(6):795-801. Authors' perspective: What is the optimum intake of vitamin C in humans? (PubMed), 155. One randomized, placebo-controlled trial has examined the effect of intravenous vitamin C administered to patients with stable angina undergoing elective coronary angioplasty (130). Gastric Cancer. Crit Care. (PubMed), 20. Higher doses (>500 mg) result in fractionally less vitamin C being absorbed as the dose increases. 14. It is important for individuals with significantly elevated blood pressure not to rely on vitamin C supplementation alone to reduce their hypertension. Lessons learned from randomised controlled trials. How long should I expect Linus Pauling's protocol to - Vitamin C Forum Similarly, higher serum vitamin C concentrations were associated with decreased risks of cancer-specific and all-cause mortality in 16,008 adults from the US National Health and Nutrition Examination Survey (NHANES) III (1994-1998) (129). Myocardial reperfusion injury: Reperfusion injury refers to tissue damage occurring at the time of blood flow restoration (reperfusion) following transient ischemia. 2000;31(10):2287-2294. Hu X, Yuan L, Wang H, et al. Am J Clin Nutr. In fact, two prospective cohort studies in Swedish men (110)and women (111)reported that high-dose single nutrient supplements of vitamin C were associated with an increased risk of cataract, especially in those on corticosteroid therapy. A few observational studies in cancer patients undergoing chemotherapy and/or radiotherapy reported that complementary intravenous vitamin C treatment was associated with a reduction in treatment-associated side effects and an improved quality of life (171). Such symptoms are not generally serious, especially if they resolve with temporary discontinuation of vitamin C supplementation. A 2015 meta-analysis of 29 randomized controlled trials found that administration of vitamin C during pregnancy, alone or in combination with a few other supplements, failed to reduce the risks of stillbirth, perinatal death, intrauterine growth restriction, preterm birth, premature rupture of membranes, and preeclampsia (88). (PubMed), 124. Reports since 1991 indicate that the Pauling Therapy works as a cure by itself, but in theory, Pauling's protocol makes an ideal oral adjunct to EDTA Chelation therapy and other more conventional therapies for all forms of cardiovascular disease, except intra . (PubMed), 121. Valls N, Gormaz JG, Aguayo R, et al. Eur J Clin Invest. Vitamin C is the primary water-soluble, non-enzymatic antioxidant in plasma and tissues. 15. Jane Higdon, Ph.D. J Rheumatol. Cancer Causes Control. Proc Natl Acad Sci U S A. (PubMed), 107. (National Academy Press), 36. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. A lower dose of 200 mg/day did not significantly affect blood lead concentration, although serum vitamin C concentrations were not different from those in the group who took 1,000 mg/day. Krajewska B, Brindell M. Urease activity and L-ascorbic acid. 2007;83(11):707-711. 2013;72(1):139-146. Roswall N, Olsen A, Christensen J, Dragsted LO, Overvad K, Tjonneland A. Micronutrient intake and breast cancer characteristics among postmenopausal women. 2012;52(9):815-829. 2012;37(12):2706-2714. Curhan GC, Willett WC, Speizer FE, Stampfer MJ. In a small, longitudinal biomarker study in 32 individuals with probable AD, a higher CSF-to-plasma vitamin C ratio at baseline was associated with a slower rate of cognitive decline at one year of follow-up (103). Carr AC, Bozonet SM, Pullar JM, Simcock JW, Vissers MC. 2007;54(73):320-324. Adjuvant effect of vitamin C on omeprazole-amoxicillin-clarithromycin triple therapy for Helicobacter pylori eradication. Because maximizing blood concentrations of vitamin C may be important in protecting against oxidative damage to cells and biological molecules, a vitamin C intake of at least 400 mg daily might benefit older adults who are at higher risk for chronic diseases caused, in part, by oxidative damage, such as heart disease, stroke, certain cancers, and cataract. Khaw KT, Bingham S, Welch A, et al. 2008;87(1):64-69. 2016;6(2):243-250. 2005;192(6):1856-1862; discussion 1862-1853. J Pharm Biomed Anal. Conversely, a 2008 meta-analysis of 14 cohort studies concluded that dietary, but not supplemental, vitamin C intake was inversely related to CHD risk (47). A population-based, prospective study, the Iowa Womens Health Study, collected baseline data on diet and supplement use in 35,159 women (aged 55-69 years) and evaluated the risk of developing non-Hodgkin lymphoma (NHL) over 19 years of follow-up (80). (PubMed), 57. I've never used his regimen in this regard, but it should help. Pauling Recommendation | Linus Pauling Institute | Oregon State University
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