ORR at RP2D (405 g/kg SC) was 69% in 19 pts treated at this dose. . Study results presented on Saturday and published in The New England Journal of Medicine suggest it could be the next promising drug to emerge in multiple myeloma an area already of intense drugmaker interest. Duration of delay from the last dose administered Action . [Bispecific antibodies in multiple myeloma]. 2023 May;23(5):310-321. doi: 10.1016/j.clml.2023.01.017. Last year at ASH, I studied andlearned more about anew bi-specific antibody drug called talquetamab. One dose-limiting toxic effect of grade 3 rash was reported in a patient who had received talquetamab at the 800-g dose level. Bispecific Antibodies in Multiple Myeloma: Opportunities to Enhance Efficacy and Improve Safety. Talquetamab, a T-Cell-Redirecting GPRC5D Bispecific Antibody for Cancers (Basel). The . The Expanding Clinical Role of Bifunctional Antibodies. Now, trials of talquetamab have shown very promising results in people with refractory myeloma. Multiple myeloma is an incurable blood cancer that affects cells inside a patient's bone marrow. Talquetamab: An Antibody for Multiple Myeloma And then there's another variety of CAR-T cell toxicity called neurologic toxicity, which has been really tough to handle in the rare cases where it's severe. It seems the total effect is a real drying effect. They were divided into two groups, one of which received the drug intravenously, and the other subcutaneously. Editors note: This story has been updated to clarify the status of Vertex and CRISPRs regulatory application. Track your myeloma and find treatment options, Journal your myeloma story in video, audio and writing, Learn from 150+ myeloma experts in video lessons, Find a free personal coach to help navigate your myeloma, Join our new social media app for myeloma patients, Tackle challenges and crush your fitness goals together, Stay up-to-date with thousands of myeloma news articles, Listen to one-on-one interviews with experts on clinical trials, Attend in-person meetings with myeloma experts, Join community groups with other patients and caregivers, Answer survey questions to advance myeloma research, Find answers to commonly asked questions when navigating HealthTree services. G protein-coupled receptor, family C, group 5, member D (GPRC5D) is an orphan receptor expressed in malignant plasma cells. A Biologics License Application has now been filed with the FDA as the company looks to bringing this novel drug to market as soon as possible. I lost a lot of sleep over this, Aronson shared, noting that her patients were distressed by these AEs. Additionally, Shain said that patients on other BiTE therapies may experience an increased risk of infection, as well as rashes, nail issues, loss of taste and other side effects all of which should be brought up to the health care team to ensure that patients can remain on therapy. So that would indicate the possibility that GPRC5D could potentially kill myeloma cells left behind after BCMA-based regimens are used! At the time of data cut-off, 76 patients had been enrolled in the trial at Mount Sinai Hospital. Nearly 60% had a very good partial response, meaning that their cancer was substantially reduced.
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